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Ultrasound-mediated gene therapy


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Schematic representation of the ultrasound technique called sonoporation that will be researched by Philips and GlyGenix Therapeutics for the targeted delivery of genes*.

Sonoporation involves the use of microbubbles that are co-injected into the bloodstream along with the therapeutic genes. When they arrive at the target organ, the microbubbles are subjected to high-intensity focused ultrasound causing them to rupture. This increases the permeability of the blood vessel wall and cell walls in the underlying tissue and facilitates the local uptake of the therapeutic genes.

*Please note that the various components have not been drawn to scale.

Graphic: Philips
Ultrasound-mediated gene therapy

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